The investigation of man´s and animal´s response to thermal stress has been studied by many workers in various respects.
Among them the biochemical and physiological studies to abnormal environmental temperature has been most popular.
But we scarcely could find the histopathological studies for the respiratory mucous membrane, especially for the condition during the changing temperature and humidity levels.
Using mice of SM strain, author attempted this experiment to study histopathological changes of nasal and paranasal mucous membrane under high temperature with high or low humidity environment.
Influences of prednisolon acetate injection before exposure to same conditions were also studied.
The animals were devided with three major groups as follows; exposure group to temperature of 401C with 855% humidity for one hour and 2 hours respectively (Group I ), exposure group to temperature 401´C with 255% humidity for one hour and 2 hours respectively (Group d ), and prednisolone treatment group before exposure to temperature of 40-!-1´C with 855% or 255% humidity for 2 hours respectively (Group 1[).
The animals were sacrified at once, 2 hours and one day after heat with high or low humidity exposure respectively and the histopathological changes of nasal muccsa were examined microscopically with control groups.
The results obtained were as follows;
1. In the group exposed to the heat with varying humidity levels, low humidity exposure (Group ff ) has a tendency to more increased mucosal change and little delayed recovery
of mucosal changes of nose and paranasal sinus than high humidity exposure (Group j ) respectively.
2. In the group(Group F) treated with prednisolone before heat with varying humidity levels, mucosal changes of nose and paranasal sinus were inclined to more significant de-creased and act toward to recovery compared with control groups (Group j , 11) respectively.
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